When the zebrafish’s severed spinal cord undergoes regeneration, a bridge forms, literally. The first cells extend projections into a distance tens of times their own length and connect across a wide gulf of the injury. Nerve cells follow. By 8 weeks, new nerve tissue has filled the gap and the animals have fully reversed their severe paralysis. /…/
Humans and zebrafish share most protein-coding genes, and CTGF is no exception. The human CTGF protein is nearly 90% similar in its amino acid building blocks to the zebrafish form. When the team added the human version of CTGF to the injury site in fish, it boosted regeneration and the fish swam better by two weeks after the injury.
/…/ The second half of the CTGF protein seems to be the key to the healing, the group found. It’s a large protein, made of four smaller parts, and it has more than one function. That might make it easier to deliver and more specific as a therapy for spinal injuries.
read the full article.. medicalxpress.com/news/2016-11-scientists-key-protein-spinal-cord.html
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