Understanding of the physical root of depression has been advanced, thanks to research by the University of Warwick, UK, and Fudan University, China. The study shows that depression affects the part of the brain which is implicated in non-reward—the lateral orbitofrontal cortex—so that sufferers of the disease feel a sense of loss and disappointment associated with not receiving rewards. Depression is also associated with reduced connectivity between the reward brain area in the medial orbitofrontal cortex and memory systems in the brain, which could account for sufferers having a reduced focus on happy memories.
read the full article.. medicalxpress.com/news/2016-10-depression-physical-source-potential-treatments.html
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