Removing cellular bookmarks smooths the path to stem cells.

Cells use specific proteins that help the cell remember what collection of genes needs to be turned on again after cell division. Removing these transcriptional bookmarks may be a key to better reprogramming of human fibroblasts to create induced pluripotent stem cells, or iPSCs.

/…/ While the more than 200 different types of human cells all have the same genome, each cell type expresses a different ensemble of genes. These expressions of specific sets of genes make a neuron distinct from a muscle cell, a fibroblast cell — a cell in connective tissue that produces collagen and other fibers — or any other type of cell.

Now UAB researchers have found that removing these transcriptional bookmarks may be a key to better reprogramming of human fibroblasts to create induced pluripotent stem cells, or iPS cells. An iPS cell is generated by epigenetic modulation from any somatic cell — usually skin or blood cells from a child or adult — to have it behave like an embryonic stem cell. As the name implies, these cells are pluripotent, which means they have the ability to form all adult cell types.

read the full article.. www.sciencedaily.com/releases/2016/09/160920130830.htm


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