Disordered protein ‘shape shifts’ to avoid crowding, study suggests.

Scientists have brought physics and biology together to further understand how cells’ crowded surfaces induce complex protein behavior. Their findings suggest that a disordered protein, called alpha-synuclein, partially escapes from the cell membrane when it runs out of space.

/…/ Cells are crowded places, and many biophysicists have studied the effects of such crowding on the structural features of biological molecules, such as proteins. These studies tend to be done in three dimensions, with proteins suspended in a dilute solution and crowded from all sides. The new research brought scientists closer to understanding how crowding on the two-dimensional surface of a cell membrane can influence protein biophysics and function.

read the article.. www.sciencedaily.com/releases/2016/09/160916093025.htm

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